Difference between revisions of "Bredesen Protocol"

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[http://www.buckinstitute.org/bredesenLab Dr. Dale Bredesen] of the Buck Institute for Research on Aging is a scientist who has been studying Alzheimer's disease for 25 years and has come up with a way to reverse it in it's early stages. His initial [http://www.impactaging.com/papers/v6/n9/full/100690.html protocol] involved 25 different interventions which individually don't make a big difference, but together are quite powerful. Each intervention is tweaked over time by using blood tests, etc. to measure their effect. In his initial paper, nine out of ten patients reversed their memory problems. The one who didn't show improvement was past the early stages of Alzheimer's.
[http://www.buckinstitute.org/bredesenLab Dr. Dale Bredesen], of the Buck Institute for Research on Aging and UCLA's Mary S. Easton Center for Alzheimer's Disease Research, is a scientist who has been studying Alzheimer's disease for 30 years and has come up with a way to reverse it in its early stages. His initial [http://www.impactaging.com/papers/v6/n9/full/100690.html protocol] involved 25 different interventions which individually don't make a big difference, but together can provide powerful synergistic benefits.  


Dr. Bredesen has since expanded the protocol and number of patients seen and is in the process of opening up trials to the wider public through [http://www.mpicognition.com MPI Cognition].  He was previously affiliated with [https://museslabs.com/ Muses Labs]. This page sets out to explain the 25 treatments in simple enough language that untrained people suffering from Alzheimer's (or their caregivers) can begin to implement the easier ones, and work with their doctors or other labs to begin the others.
Each intervention is tweaked over time by using blood tests, body measurements, imaging and similar guides to measure its effect. In his initial paper, nine out of ten patients reversed their memory problems and returned to their former healthy level of functioning. The one who didn't show improvement was past the early stages of Alzheimer's.


Here are the 25 interventions used in the Bredesen [http://www.impactaging.com/papers/v6/n9/full/100690.html protocol] to reverse mild Alzheimer's:
Dr. Bredesen has since expanded the protocol and number of patients seen. He is in the process of making it available to the wider public with the help of doctors certified in the protocol through [http://www.drbredesen.com/ MPI Cognition]. 
 
Dr. Bredesen was previously affiliated with [https://museslabs.com/ Muses Labs].
 
This page sets out to explain the 25 treatments in simple enough language that untrained people suffering from Alzheimer's (or their caregivers) can begin to implement the easier ones while working with their doctors or other labs to begin the others.
 
Here are the interventions used in The Bredesen [http://www.impactaging.com/papers/v6/n9/full/100690.html Protocol™] to reverse mild Alzheimer's:


1. [[Optimize diet]]
1. [[Optimize diet]]
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6. [[Brain stimulation]]
6. [[Brain stimulation]]


7. [[Homocysteine less than 7]]
7. [[Homocysteine less than 6]] (earlier version of the protocol was < 7)


8. [[Serum B12 greater than 500]]
8. [[Serum B12 greater than 500]]


9. [[CRP less than 1.0; A/G greater than 1.5]]
9. [[CRP less than 1.0; A/G greater than 1.8]] (earlier version of the protocol was > 1.5)


10. [[Fasting insulin less than 7; HgbA1c less than 5.5]]
10. [[Fasting insulin less than 5; HgbA1c less than 5.6]] (earlier version of the protocol was Fasting insulin <7; HgbA1c <5.5)


11. [[Hormone balance]]
11. [[Hormone balance]]
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14. [[Cognitive enhancement]]
14. [[Cognitive enhancement]]


15. [[25OH-D3 = 50-100ng/ml]]
15. [[25OH-D3 = 50-80ng/ml]] (earlier version of the protocol was 50-100)


16. [[Increase NGF]]
16. [[Increase NGF]]
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[[Lab testing information]]
[[Lab testing information]]
[[Supplement ordering]]
'''<big>=== For further reading and information on Dr Bredesen's research ===</big>'''
'''<big>Book</big>'''
Dr Bredesen's book, '''''The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline''''', published August 22, 2017.  [https://www.amazon.com/End-Alzheimers-Program-Prevent-Cognitive/dp/0735216207/ref=sr_1_1?ie=UTF8&qid=1501354240&sr=8-1&keywords=bredesen Amazon link to Dr Bredesen's book]
<big>'''Videos and interviews'''</big>
* Videos are available on the MPI Cognition website [http://www.mpicognition.com www.mpicognition.com]
* There is a long, but very good STEM Talk interview with Dr Bredesen available on YouTube, Published on Jun 1, 2016 [https://www.youtube.com/watch?v=HS7VZydS8HI Episode 12 Dale Bredesen discusses the metabolic factors underlying Alzheimer’s Disease]
* Presentation given by Dr Bredesen at the Integrative Healthcare Symposium (IHS) Pre-Conference - Feb. 24, 2016 in Midtown, New York City [https://vimeo.com/173061978 IHS 2016 -Cognitive Health: Dawn of the Era of Treatable Alzheimer’s Disease]
* 36 Holes in the Roof, comes with a very nice illustrative video, published Mar 25, 2015 [http://www.clinicaleducation.org/resources/reviews/36-holes-in-the-roof-the-dawn-of-the-era-of-treatable-and-preventable-alzheimers-disease/ 36 ‘Holes in the Roof’ The Dawn of the Era of Treatable and Preventable Alzheimer’s Disease]
* Dr Gundry's interview with Dr Bredesen, Published on Aug 21, 2017 [https://www.youtube.com/watch?v=p6lkRXaQKwk&feature=youtu.be Dr. Steven Gundry interviews Dr Dale Bredesen about "The End of Alzheimer's"]
* Dr Mercola's interview with Dr Bredesen, with a fair discussion of ApoE4, Published on Aug 25, 2017, [https://www.youtube.com/watch?v=qrQyxWP-S2s&feature=youtu.be Dr. Mercola Interviews Dr. Bredesen About ReCODE Protocol]
<big>'''Dr Bredesen's Papers'''</big>
* The first version of Dr Bredesen’s protocol (which is similar to the above) can be found in his paper: '''''Reversal of cognitive decline: A novel therapeutic program''''', published September 2014, https://www.ncbi.nlm.nih.gov/pubmed/25324467
Subsequent papers of Dr Bredesen do not address his protocol, but further examine his findings, they are:
* '''''Metabolic profiling distinguishes three subtypes of Alzheimer's disease''''', published in August 2015, https://www.ncbi.nlm.nih.gov/pubmed/26343025
* '''''Direct Transcriptional Effects of Apolipoprotein E''''' published January 2016, Dr Bredesen is co-author.  https://www.ncbi.nlm.nih.gov/pubmed/26791201
* '''''Inhalational Alzheimer’s Disease: An unrecognized – and treatable epidemic''''', published February 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789584/
* '''''Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease''''', published September 2017. https://www.ncbi.nlm.nih.gov/pubmed/28879423

Revision as of 09:05, 14 September 2017

Dr. Dale Bredesen, of the Buck Institute for Research on Aging and UCLA's Mary S. Easton Center for Alzheimer's Disease Research, is a scientist who has been studying Alzheimer's disease for 30 years and has come up with a way to reverse it in its early stages. His initial protocol involved 25 different interventions which individually don't make a big difference, but together can provide powerful synergistic benefits.

Each intervention is tweaked over time by using blood tests, body measurements, imaging and similar guides to measure its effect. In his initial paper, nine out of ten patients reversed their memory problems and returned to their former healthy level of functioning. The one who didn't show improvement was past the early stages of Alzheimer's.

Dr. Bredesen has since expanded the protocol and number of patients seen. He is in the process of making it available to the wider public with the help of doctors certified in the protocol through MPI Cognition.

Dr. Bredesen was previously affiliated with Muses Labs.

This page sets out to explain the 25 treatments in simple enough language that untrained people suffering from Alzheimer's (or their caregivers) can begin to implement the easier ones while working with their doctors or other labs to begin the others.

Here are the interventions used in The Bredesen Protocol™ to reverse mild Alzheimer's:

1. Optimize diet

2. Enhance autophagy, ketogenesis

3. Reduce stress

4. Optimize sleep

5. Exercise

6. Brain stimulation

7. Homocysteine less than 6 (earlier version of the protocol was < 7)

8. Serum B12 greater than 500

9. CRP less than 1.0; A/G greater than 1.8 (earlier version of the protocol was > 1.5)

10. Fasting insulin less than 5; HgbA1c less than 5.6 (earlier version of the protocol was Fasting insulin <7; HgbA1c <5.5)

11. Hormone balance

12. GI health

13. Reduction of Aß

14. Cognitive enhancement

15. 25OH-D3 = 50-80ng/ml (earlier version of the protocol was 50-100)

16. Increase NGF

17. Provide synaptic structural components

18. Optimize antioxidants

19. Optimize Zn:fCu ratio

20. Ensure nocturnal oxygenation

21. Optimize mitochondrial function

22. Increase focus

23. Increase SirT1 function

24. Exclude heavy metal toxicity

25. MCT effects

26. Inhalational Alzheimer's

Lab testing information

Supplement ordering


=== For further reading and information on Dr Bredesen's research ===

Book

Dr Bredesen's book, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline, published August 22, 2017. Amazon link to Dr Bredesen's book

Videos and interviews

Dr Bredesen's Papers

  • The first version of Dr Bredesen’s protocol (which is similar to the above) can be found in his paper: Reversal of cognitive decline: A novel therapeutic program, published September 2014, https://www.ncbi.nlm.nih.gov/pubmed/25324467

Subsequent papers of Dr Bredesen do not address his protocol, but further examine his findings, they are: