Bredesen Protocol

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Introduction

Dr. Dale Bredesen has created a protocol that involves multiple interventions to address specific components of AD pathology that research has identified to date. Each intervention is measured and tweaked over time by using blood tests, cognitive evaluations and other markers of overall health improvements. His analogy is to think of AD as a leaky roof - there are as many as 36 leaks in in the AD roof that need to be addressed to stop the problem. Not every patient will have the same leaks, and the protocol is customized based on the patient’s genetics, current health and lifestyle.

His first published paper on the protocol, Reversal of Cognitive Decline, highlighted 10 case studies. Of those 10 people, nine showed enough improvement to return to normal life activities. Since then, several hundred people with cognitive impairment have followed the protocol, and most have seen a reversal of cognitive impairment. Dr. Bredesen is currently partnering with the Cleveland Clinic to test the protocol in a larger trial.

Although Bredesen does not see private patients, he is in the process of making it available to the wider public with the help of doctors certified in the protocol through MPI Cognition. His previous affiliation with Muses Labs has ended.


Bredesen’s protocol has not been tested as a preventative. That said, research has shown that amyloid-β is deposited in E4 carriers as early as their thirties so addressing components early will likely lead to better health in aging. Members on the APOE4.Info forum who follow the protocol report improvements not only in health, but cognition, even if they do not have an SCI or MCI diagnosis.


The following list includes summaries, a selection of research references and suggested strategies related to the intervention targets of the protocol.

Diet Strategies

Optimize diet

Enhance autophagy, ketogenesis

MCT effects


Lifestyle Strategies

Reduce stress

Optimize sleep

Exercise

Rule out sleep apnea

Optimize mitochondrial function


Lab Tests to Track and Treat

Homocysteine

B vitamins

Inflammation

Insulin sensitivity (insulin and blood glucose)

Optimize antioxidants  ???

Zn:fCu ratio

Vitamin D (Editing note: Update info from 25OH-D3 = 50-80ng/ml)

Rule out heavy metal toxicity


Brain Strategies

Brain stimulation

Reduction of Aß

Cognitive enhancement

Increase NGF

Provide synaptic structural components

Increase focus

Increase SirT1 function


Inhalational Alzheimer's (editing note: update to types of AD)


Resources

Lab testing information

Supplement ordering


=== For further reading and information on Dr Bredesen's research ===

Book

Dr Bredesen's book, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline, published August 22, 2017. Amazon link to Dr Bredesen's book

Videos and interviews


Dr Bredesen's Papers

  • The first version of Dr Bredesen’s protocol (which is similar to the above) can be found in his paper: Reversal of cognitive decline: A novel therapeutic program, published September 2014, https://www.ncbi.nlm.nih.gov/pubmed/25324467

Subsequent papers of Dr Bredesen do not address his protocol, but further examine his findings, they are: