Bredesen Protocol

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Dr. Dale Bredesen of the Buck Institute for Research on Aging is a scientist who has been studying Alzheimer's disease for 25 years and has come up with a way to reverse it in it's early stages. His initial protocol involved 25 different interventions which individually don't make a big difference, but together are quite powerful. Each intervention is tweaked over time by using blood tests, etc. to measure their effect. In his initial paper, nine out of ten patients reversed their memory problems. The one who didn't show improvement was past the early stages of Alzheimer's.

Dr. Bredesen has since expanded the protocol and number of patients seen and is in the process of opening up trials to the wider public through MPI Cognition. He was previously affiliated with Muses Labs. This page sets out to explain the 25 treatments in simple enough language that untrained people suffering from Alzheimer's (or their caregivers) can begin to implement the easier ones, and work with their doctors or other labs to begin the others.

Here are the 25 interventions used in the Bredesen protocol to reverse mild Alzheimer's:

1. Optimize diet

2. Enhance autophagy, ketogenesis

3. Reduce stress

4. Optimize sleep

5. Exercise

6. Brain stimulation

7. Homocysteine less than 7

8. Serum B12 greater than 500

9. CRP less than 1.0; A/G greater than 1.5

10. Fasting insulin less than 7; HgbA1c less than 5.5

11. Hormone balance

12. GI health

13. Reduction of Aß

14. Cognitive enhancement

15. 25OH-D3 = 50-100ng/ml

16. Increase NGF

17. Provide synaptic structural components

18. Optimize antioxidants

19. Optimize Zn:fCu ratio

20. Ensure nocturnal oxygenation

21. Optimize mitochondrial function

22. Increase focus

23. Increase SirT1 function

24. Exclude heavy metal toxicity

25. MCT effects