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The following is a non-technical summary of some differences between APOE-ε4s and others in the effects of various treatment/prevention modalities:
http://www.trackyourplaque.com/forum/topics.aspx?ID=8216
A very useful review of the mechanisms by which the ApoE4 protein can cause harm, and how that harm might be mitigated, is here:
"Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy"
A paper that explores the clinical relevance of APOE-ε4 (carriers might want to refer their doctors to this paper) is here:
"The potential applications of Apolipoprotein E in personalized medicine"