Optimize Zn:fCu ratio
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The nineteenth intervention to reverse mild Alzheimer's in the Bredesen Protocol is:
- Goal: Optimize Zn:fCu ratio to 1:1
- Approach: Depends on values obtained
Zinc is involved in multiple Alzheimer's-related metabolic processes, such as insulin resistance, chronic inflammation, ADAM10 proteolytic activity, and hormonal signaling.
One of the symptoms, signs, and laboratory values suggestive of type 3 Alzheimer's disease is low serum zinc (<75mcg/dl) or RBC zinc, or high copper:zinc ratio (>1.3)
References
- Zinc deficiency and zinc therapy efficacy with reduction of serum free copper in Alzheimer's disease
- Metabolic profiling distinguishes three subtypes of Alzheimer's disease
- Inhalational Alzheimer's disease: an unrecognized - and treatable - epidemic
Next Intervention
The next intervention in the Bredesen Protocol is Ensure nocturnal oxygenation.