ApoE4 Research

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Here are some ideas about what can be done to focus more research on the APOE-ε4 allele and the protein it produces, ApoE4.

  • Encourage researchers to pool existing data to get statistical significance. There are many researchers sitting on unpublished data looking at lifestyle and even drug interventions and their relation to outcomes based on ε4 status. The numbers of ε4 homozygotes in any particular study are in nearly all cases (I'd guess) too small to reach statistical significance, but if the data were pooled it would surely permit some at least tentative, if not solid conclusions. Asking researchers about unreported data on an effect caused by APOE isoform is also a way to raise awareness among them, or to remind them, about how important it is. See "Recent studies that did not report on APOE status."
  • Those ε4 homozygotes who are interested in participating in trials could contact researchers and say they are available to be studied (heterozygotes could of course also be studied). Some researchers would jump at the chance to research non-demented ε4 homozygotes, since the expense of finding ε4 homozygotes in younger populations is enormous.

Additional information about participation in the clinical trial can be found at:

Other research teams or organizations that could be contacted:

Among ADDF's many research efforts is a focus on ApoE. See "Apolipoprotein e4: not just a genetic risk factor"

Status: 23andMe is not currently pursuing ApoE-related research.

Any ε4 carriers who feel comfortable sharing their data (anonymously) can upload their sequencing and health information to existing open genome projects: