The eleventh intervention to reverse mild Alzheimer's in the Bredesen Protocol is:
- Goal: Hormone balance
- Approach: Optimize fT3, fT4, E2, T, progesterone, pregnenolone, cortisol
fT3 (Free Triiodothyronine) is a thyroid hormone with three iodine atoms that affects almost every process in the body, including growth and development, metabolism, body temperature, and heart rate. It increases the body's oxygen and energy consumption. It stimulates the production of the fatty coverings of nerves, the production of nerve signalling molecules, and the parts of nerves that act as wires. It may increase serotonin in the brain.
fT4 (Free Thyroxine) is a thyroid hormone with four iodine atoms that gets turned into fT3 in the body.
E2 (Estradiol) is the primary female sex hormone (it has two alcohol groups). It is an antioxidants, has been found to protect brain cells, and is made from progesterone and pregnenolone.
Progesterone is involved in the menstrual cycle, pregnancy and development of embryos, and has a protective effect on damaged brain tissue.
Pregnenolone is a steroid hormone. It is the precursor of many other steroid hormones and acts as a neurosteroid itself.
T (Testosterone) is the primary male sex hormone. Attention, memory, and spatial ability are affected by testosterone, and low or high testosterone levels may be a risk factor for cognitive decline and possibly Alzheimer's.
Cortisol is a stress hormone. Long-term exposure to cortisol damages cells in the hippocampus and impairs learning. Cortisol also decreases memory retrieval of already stored information.
- Next generation therapeutics for Alzheimer's disease
- Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction