Optimize mitochondrial function

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The twenty first intervention to reverse mild Alzheimer's in the Bredesen Protocol is:

Goal: Optimize mitochondrial function
Approach: CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine

Mitochondria are the organelles in your cells that generate energy. CoQ Coenzyme Q10 is a molecule in the mitochondria that is essential to producing energy. Ubiquinol is its electron-rich (reduced) form that is better absorbed.

a-lipoic acid can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.

PQQ (pyrroloquinoline quinone) prevents cognitive deficit caused by oxidative stress in rats.

NAC (N-acetylcysteine) 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.

Acetyl-L-carnitine (ALCAR) 500mg per day.

Alzheimer's patients with low Se (Selenium) in their blood have been found to have more problems with cognitive function.

Optimize Zn:fCu ratio

Resveratrol Stabilizes Amyloid in Alzheimer's

Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate (Vitamin C) and other nutrients with neuroprotective properties.

Thiamine 2.5mg. Oral thiamine trials have been shown to improve the cognitive function of patients with AD. See Thiamine at this Wiki for a more in-depth introduction to the literature.


Next Intervention

The next intervention in the Bredesen Protocol is Increase focus.