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by Brian4
Sun Aug 18, 2019 12:53 pm
Forum: Meet-Ups
Topic: Calling all Alzheimer's Activists!
Replies: 154
Views: 9079

Re: Calling all Alzheimer's Activists!

I am REALLY disappointed I had to miss this (a conference call scheduled for earlier in the day went way, way over), but I will hope to attend the next meeting.

It sounds like tremendous progress was made. Congratulations!

Brian
by Brian4
Mon Aug 12, 2019 6:16 pm
Forum: Getting Started
Topic: Oldest APOE 4/4
Replies: 12
Views: 2714

Re: Oldest APOE 4/4

A Finnish study found a 4/4 woman centenarian (exact age not reported) who was cognitively normal.

https://www.ncbi.nlm.nih.gov/pubmed/7746404/
by Brian4
Sat Aug 10, 2019 4:41 am
Forum: Meet-Ups
Topic: Calling all Alzheimer's Activists!
Replies: 154
Views: 9079

Re: Calling all Alzheimer's Activists!

Julie, great initiative! So to be clear: the meeting time is 4 p.m. EDT, Aug. 13, right?
by Brian4
Sun Jun 02, 2019 2:31 am
Forum: Prevention and Treatment
Topic: Experiences with Low Dose Naltrexone
Replies: 68
Views: 6035

Re: Experiences with Low Dose Naltrexone

Julie! Wow, I must express the one pole of horror at your accident, and the other of joy about your success with LDN. (And by the way sorry for being so absent here at our forum. My job is full-bore.) My experience with LDN (at 4 mg now) is hard to assess. I started it mainly because of ME/CFS/SEID,...
by Brian4
Sun May 19, 2019 9:56 am
Forum: The Social Hour
Topic: Europeans?
Replies: 2
Views: 891

Re: Europeans?

Hello Csaebye, and welcome! There are plenty of Europeans here, and many Scandinavians. Most of the Scandinavians seem to be Swedes from around Stockholm, but at least one is in Lund, across the bridge from you if you per chance are in Copenhagen. So perhaps the basis of a get-together exists near y...
by Brian4
Tue Apr 23, 2019 9:47 am
Forum: Science and Research
Topic: Designing an E4 Fasting trial...
Replies: 30
Views: 3305

Re: Designing an E4 Fasting trial...

Fiver, great idea! Eager subjects, ready to follow protocols exactly, possessing lots of medical records – not easy for researchers to find.
by Brian4
Tue Apr 23, 2019 8:54 am
Forum: Science and Research
Topic: Designing an E4 Fasting trial...
Replies: 30
Views: 3305

Re: Designing an E4 Fasting trial...

We had spoken some time ago about encouraging Longo to do a fasting trial in humans, and, as I recall, his response was that he was more interested in doing mice studies. Looks like he's launching a trial with his diet and dementia. No info on whether he's stratifying for APOE status: https://www.be...
by Brian4
Wed Apr 10, 2019 7:15 am
Forum: Science and Research
Topic: Fish oil and dementia: lack of (consistent) efficacy explained?
Replies: 3
Views: 548

Fish oil and dementia: lack of (consistent) efficacy explained?

Summary by ConsumerLab of new study: A study in Sweden among people with mild to moderate Alzheimer's disease found that daily supplementation with 1,700 mg of DHA and 600 mg of EPA for six months benefitted only those with adequate B vitamin status (determined by blood levels of homocysteine). In c...
by Brian4
Tue Apr 09, 2019 1:03 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 14
Views: 1356

Re: Using RAPA for AD prevention

Hello Newtothis3/4, Some cautions about rapamycin: <> Dosing probably needs to be much, much higher to have a significant effect, so high that safety could be a concern: - 126 ppm rapamycin in chow (Bitto et al) is the human equivalent of 90 mg/day - 14 ppm (Harrison and others) is the human equival...
by Brian4
Sun Mar 31, 2019 2:04 am
Forum: Prevention and Treatment
Topic: Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease
Replies: 1
Views: 587

Re: Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease

Cool! Let's a hope full-blown study is done, one with isolation of the independent variables. “a low carbohydrate/high fat diet, also known as the ketogenic diet, calorie restriction (fasting), and both physical and cognitive exercises....” We really can't conclude anything about ketosis and dementi...

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