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by Brian4
Sun Jul 19, 2020 7:22 am
Forum: Prevention and Treatment
Topic: Sources of Aluminum in our daily lives, safer alternatives, words to look for on labels
Replies: 54
Views: 11326

Re: Sources of Aluminum in our daily lives, safer alternatives, words to look for on labels

Laurie, thanks so much for the extremely helpful info! As I mentioned before, I'm using ZeroWater, but I take various forms (mostly drops) of supplemental Si throughout the day. The frequent use of Al salts in water treatment facilities is disturbing.... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...
by Brian4
Fri Jul 10, 2020 5:19 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 7221

Re: Using RAPA for AD prevention

I decided not to take rapamycin, partly for reasons cited earlier (dosage needed for effect is probably huge), but mainly because I'd rather wait until an mTOR inhibitor is developed with a very short half-life, so that one could take it late in the evening and it would reinforce the natural mTOR r...
by Brian4
Thu Jul 09, 2020 5:43 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 39
Views: 7221

Re: Using RAPA for AD prevention

I see that most of these posts are from almost a year ago. I would love to know if anyone has followed through and started taking rapamycin and or metformin. If not why? Hi Bosco, I decided not to take rapamycin, partly for reasons cited earlier (dosage needed for effect is probably huge), but main...
by Brian4
Sun Feb 16, 2020 2:33 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 6255

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

but without the toxic effects that I assume PH002 would have on mice and men
Why do you assume that?
by Brian4
Thu Feb 13, 2020 7:00 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 6255

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

Do you know why PH002 itself isn't a therapy? Good question! It would not be that hard to 1) order some: https://www.emdmillipore.com/US/en/product/ApoE4-Modulator-PH002-Calbiochem,EMD_BIO-178477 2) do a rodent safety and dose discovery study, then 3) do a Phase I trial in humans. Last I checked, E...
by Brian4
Sun Dec 29, 2019 5:33 am
Forum: Science and Research
Topic: Does Alzheimer's Disease Stem From Infection?
Replies: 6
Views: 1531

Re: Does Alzheimer's Disease Stem From Infection?

Hi everyone,

A new report has come out questioning the link between at least some herpes viruses and AD:

https://www.bcm.edu/news/alzheimers-dis ... alzheimers

I haven't yet gotten a hold of the full text, so not sure about the details.

Brian
by Brian4
Sun Aug 18, 2019 12:53 pm
Forum: Meet-Ups
Topic: Calling all Alzheimer's Activists!
Replies: 154
Views: 20806

Re: Calling all Alzheimer's Activists!

I am REALLY disappointed I had to miss this (a conference call scheduled for earlier in the day went way, way over), but I will hope to attend the next meeting.

It sounds like tremendous progress was made. Congratulations!

Brian
by Brian4
Mon Aug 12, 2019 6:16 pm
Forum: Getting Started
Topic: Oldest APOE 4/4
Replies: 12
Views: 3787

Re: Oldest APOE 4/4

A Finnish study found a 4/4 woman centenarian (exact age not reported) who was cognitively normal.

https://www.ncbi.nlm.nih.gov/pubmed/7746404/
by Brian4
Sat Aug 10, 2019 4:41 am
Forum: Meet-Ups
Topic: Calling all Alzheimer's Activists!
Replies: 154
Views: 20806

Re: Calling all Alzheimer's Activists!

Julie, great initiative! So to be clear: the meeting time is 4 p.m. EDT, Aug. 13, right?

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