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by Brian4
Fri Jul 10, 2020 5:19 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 29
Views: 4063

Re: Using RAPA for AD prevention

I decided not to take rapamycin, partly for reasons cited earlier (dosage needed for effect is probably huge), but mainly because I'd rather wait until an mTOR inhibitor is developed with a very short half-life, so that one could take it late in the evening and it would reinforce the natural mTOR r...
by Brian4
Thu Jul 09, 2020 5:43 am
Forum: Our Stories
Topic: Using RAPA for AD prevention
Replies: 29
Views: 4063

Re: Using RAPA for AD prevention

I see that most of these posts are from almost a year ago. I would love to know if anyone has followed through and started taking rapamycin and or metformin. If not why? Hi Bosco, I decided not to take rapamycin, partly for reasons cited earlier (dosage needed for effect is probably huge), but main...
by Brian4
Sun Feb 16, 2020 2:33 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 5464

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

but without the toxic effects that I assume PH002 would have on mice and men
Why do you assume that?
by Brian4
Thu Feb 13, 2020 7:00 pm
Forum: Science and Research
Topic: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes
Replies: 29
Views: 5464

Re: Erasing the damage caused by apoE4 in human genes? New study by Gladstone Institutes

Do you know why PH002 itself isn't a therapy? Good question! It would not be that hard to 1) order some: https://www.emdmillipore.com/US/en/product/ApoE4-Modulator-PH002-Calbiochem,EMD_BIO-178477 2) do a rodent safety and dose discovery study, then 3) do a Phase I trial in humans. Last I checked, E...
by Brian4
Sun Dec 29, 2019 5:33 am
Forum: Science and Research
Topic: Does Alzheimer's Disease Stem From Infection?
Replies: 6
Views: 1295

Re: Does Alzheimer's Disease Stem From Infection?

Hi everyone,

A new report has come out questioning the link between at least some herpes viruses and AD:

https://www.bcm.edu/news/alzheimers-dis ... alzheimers

I haven't yet gotten a hold of the full text, so not sure about the details.

Brian
by Brian4
Sun Aug 18, 2019 12:53 pm
Forum: Meet-Ups
Topic: Calling all Alzheimer's Activists!
Replies: 154
Views: 16657

Re: Calling all Alzheimer's Activists!

I am REALLY disappointed I had to miss this (a conference call scheduled for earlier in the day went way, way over), but I will hope to attend the next meeting.

It sounds like tremendous progress was made. Congratulations!

Brian
by Brian4
Mon Aug 12, 2019 6:16 pm
Forum: Getting Started
Topic: Oldest APOE 4/4
Replies: 12
Views: 3382

Re: Oldest APOE 4/4

A Finnish study found a 4/4 woman centenarian (exact age not reported) who was cognitively normal.

https://www.ncbi.nlm.nih.gov/pubmed/7746404/
by Brian4
Sat Aug 10, 2019 4:41 am
Forum: Meet-Ups
Topic: Calling all Alzheimer's Activists!
Replies: 154
Views: 16657

Re: Calling all Alzheimer's Activists!

Julie, great initiative! So to be clear: the meeting time is 4 p.m. EDT, Aug. 13, right?
by Brian4
Sun Jun 02, 2019 2:31 am
Forum: Prevention and Treatment
Topic: Experiences with Low Dose Naltrexone
Replies: 84
Views: 14821

Re: Experiences with Low Dose Naltrexone

Julie! Wow, I must express the one pole of horror at your accident, and the other of joy about your success with LDN. (And by the way sorry for being so absent here at our forum. My job is full-bore.) My experience with LDN (at 4 mg now) is hard to assess. I started it mainly because of ME/CFS/SEID,...

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