Serum Cholesterol and Incident Alzheimer's Disease Findings From the Adult Changes in Thought Study Markham, et al. J. of the American Geriatric Society, 2018;66(12):2344-2352. This study indicates that what might be considered modestly raised non-HDL cholesterol is associated with the lowest incide...

After reading this book, I added black-out shades to the bedroom windows and turned down the thermostat five degrees before bed. I also removed the clock from the bedroom in an effort not to stir up more concern about how many hours and minutes I have slept. These two articles may be of interest...i...

You may be interested in a discussion with Nir Barzilai, who carried out a small study of centenarians with a succinct gene pool, in which he noted healthy aging despite life style and APOE status. You may have won the genetic jackpot if your parents are both long-lived and aging with relatively goo...

“Physical Activity, Common Brain Pathologies, and Cognition in Community-dwelling older adults” - Neurology, January 16, 2019, Aron Buchman – Rush Memory Aging Project. Using accelerometers, these researchers measured all physical activity (all movement…not just exercise), and found better neurocogn...

“APOE attenuates unresolvable inflammation by complex formation with activated C1q” – Yin, C, et al, Nature Medicine, online 1/28/2019. Study in mice with APOE ko, APOE3 ki and APOE4 ki fed normal chow or high fat chow reveals compromise of blood brain barrier in APOE-ko and in APOE4-ki mice fed hig...

I see no reason to ignore research that is more than five years old unless the methodology has improved or new scientific breakthroughs/insights have led to new testing methods or interpretations. Take a look at the recently discussed Bredesen paper citing research published in 1998. But I do take t...

Sorry...my new posting appears to have knocked this very important discussion off of the main forum view, so I am posting here to get it back. I am a new member, and I am finding out how the forums work one error at a time. I am very interested in this discussion, in part because I had symptoms that...

“An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer’s disease – a cohort study of 95,442 individuals.” 2018. Alzheimer’s & Dementia. Rasmussen, K., et al. pages 1 – 13. My non-expert analysis of this research article. Complement C3 is a protein that (along with other proteins) ...

I could not find the research article I referenced in an earlier post on this thread, but I did a little digging and uncovered the following articles, many of which are reviews of research articles on this topic, and have provided quotes from the articles: H.M. Schipper, “Apolipoprotein E: Implicati...

Perhaps this has already been posted? I saw it on the Alzforum website - The development of biomarkers for Alzheimer’s and other neurodegenerative diseases is accelerating rapidly, with blood tests and new fluid and imaging markers on the horizon. However, developers must contend with an uncertain p...