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by frankiesfriend
Thu Jan 31, 2019 5:55 am
Forum: Science and Research
Topic: Hypothesis that deficiency of Innate Immunity protein causes AD
Replies: 15
Views: 2177

Re: Hypothesis that deficiency of Innate Immunity protein causes AD

“APOE attenuates unresolvable inflammation by complex formation with activated C1q” – Yin, C, et al, Nature Medicine, online 1/28/2019. Study in mice with APOE ko, APOE3 ki and APOE4 ki fed normal chow or high fat chow reveals compromise of blood brain barrier in APOE-ko and in APOE4-ki mice fed hig...
by frankiesfriend
Fri Jan 25, 2019 5:17 am
Forum: The Social Hour
Topic: If you should choose to drink alcohol -- which is best?
Replies: 34
Views: 7734

Re: If you should choose to drink alcohol -- which is best?

I see no reason to ignore research that is more than five years old unless the methodology has improved or new scientific breakthroughs/insights have led to new testing methods or interpretations. Take a look at the recently discussed Bredesen paper citing research published in 1998. But I do take t...
by frankiesfriend
Wed Jan 23, 2019 10:45 am
Forum: Science and Research
Topic: Gut health research
Replies: 10
Views: 2319

Re: Gut health research

Sorry...my new posting appears to have knocked this very important discussion off of the main forum view, so I am posting here to get it back. I am a new member, and I am finding out how the forums work one error at a time. I am very interested in this discussion, in part because I had symptoms that...
by frankiesfriend
Wed Jan 23, 2019 10:39 am
Forum: Science and Research
Topic: Hypothesis that deficiency of Innate Immunity protein causes AD
Replies: 15
Views: 2177

Hypothesis that deficiency of Innate Immunity protein causes AD

“An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer’s disease – a cohort study of 95,442 individuals.” 2018. Alzheimer’s & Dementia. Rasmussen, K., et al. pages 1 – 13. My non-expert analysis of this research article. Complement C3 is a protein that (along with other proteins) ...
by frankiesfriend
Wed Jan 23, 2019 6:31 am
Forum: The Social Hour
Topic: If you should choose to drink alcohol -- which is best?
Replies: 34
Views: 7734

Re: If you should choose to drink alcohol -- which is best?

I could not find the research article I referenced in an earlier post on this thread, but I did a little digging and uncovered the following articles, many of which are reviews of research articles on this topic, and have provided quotes from the articles: H.M. Schipper, “Apolipoprotein E: Implicati...
by frankiesfriend
Mon Jan 21, 2019 2:12 pm
Forum: Announcements and Events
Topic: FDA Draft of AD biomarkers -deadline for comment 2/11/2019
Replies: 0
Views: 630

FDA Draft of AD biomarkers -deadline for comment 2/11/2019

Perhaps this has already been posted? I saw it on the Alzforum website - The development of biomarkers for Alzheimer’s and other neurodegenerative diseases is accelerating rapidly, with blood tests and new fluid and imaging markers on the horizon. However, developers must contend with an uncertain p...
by frankiesfriend
Sat Jan 19, 2019 11:36 am
Forum: Our Stories
Topic: Anxiety and APOE4
Replies: 14
Views: 3398

Re: Anxiety and APOE4

Your anxiety is understandable, and it is overwhelming to read about the many aspects of lifestyle changes that would favor brain health. You are fortunate, however, to learn your status when you are so young and can evaluate and modify your lifestyle to avoid developing Alzheimer's. It must have be...
by frankiesfriend
Sat Jan 19, 2019 8:36 am
Forum: The Social Hour
Topic: If you should choose to drink alcohol -- which is best?
Replies: 34
Views: 7734

Re: If you should choose to drink alcohol -- which is best?

A few months ago I read a review article on alcohol risks and Alzheimer's. I was particularly interested in studies that teased out differences, if any, related to genetics. I found it interesting that there were many research articles that indicated no increased risk of AD with light to moderate al...
by frankiesfriend
Sun Jan 13, 2019 2:23 pm
Forum: Getting Started
Topic: New member questions
Replies: 13
Views: 2263

Re: New member questions

Thank you everyone for your insight and for sharing your personal experiences. My mother was only five years older than I am right now when she was diagnosed with AD. She probably had mixed dementia and suffered terribly from delusions and emotional turmoil. Watching this was heartrending, and the q...
by frankiesfriend
Sun Jan 13, 2019 7:31 am
Forum: Science and Research
Topic: 'Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later'
Replies: 9
Views: 1474

Re: 'Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later'

I am re-reading Bredesen's "The End of Alzheimer's", having noted that he has an updated version. Just last night, I ran across an assertion that very low triglycerides (especially under 50 mg/dl), are observed in patients who have toxicity-related Alzheimer's. I remember when I read this ...

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