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by frankiesfriend
Fri Feb 22, 2019 5:46 pm
Forum: Science and Research
Topic: Cholesterol level sweet spot
Replies: 2
Views: 925

Cholesterol level sweet spot

Serum Cholesterol and Incident Alzheimer's Disease Findings From the Adult Changes in Thought Study Markham, et al. J. of the American Geriatric Society, 2018;66(12):2344-2352. This study indicates that what might be considered modestly raised non-HDL cholesterol is associated with the lowest incide...
by frankiesfriend
Sat Feb 09, 2019 4:22 pm
Forum: Science and Research
Topic: Why We Sleep, Matthew Walker
Replies: 6
Views: 1670

Re: Why We Sleep, Matthew Walker

After reading this book, I added black-out shades to the bedroom windows and turned down the thermostat five degrees before bed. I also removed the clock from the bedroom in an effort not to stir up more concern about how many hours and minutes I have slept. These two articles may be of interest...i...
by frankiesfriend
Thu Feb 07, 2019 5:44 am
Forum: Prevention and Treatment
Topic: Full Keto diet or not?
Replies: 28
Views: 6311

Re: Full Keto diet or not?

You may be interested in a discussion with Nir Barzilai, who carried out a small study of centenarians with a succinct gene pool, in which he noted healthy aging despite life style and APOE status. You may have won the genetic jackpot if your parents are both long-lived and aging with relatively goo...
by frankiesfriend
Fri Feb 01, 2019 7:48 am
Forum: Prevention and Treatment
Topic: Low AD even with AD neuropathologies
Replies: 0
Views: 415

Low AD even with AD neuropathologies

“Physical Activity, Common Brain Pathologies, and Cognition in Community-dwelling older adults” - Neurology, January 16, 2019, Aron Buchman – Rush Memory Aging Project. Using accelerometers, these researchers measured all physical activity (all movement…not just exercise), and found better neurocogn...
by frankiesfriend
Thu Jan 31, 2019 5:55 am
Forum: Science and Research
Topic: Hypothesis that deficiency of Innate Immunity protein causes AD
Replies: 15
Views: 3203

Re: Hypothesis that deficiency of Innate Immunity protein causes AD

“APOE attenuates unresolvable inflammation by complex formation with activated C1q” – Yin, C, et al, Nature Medicine, online 1/28/2019. Study in mice with APOE ko, APOE3 ki and APOE4 ki fed normal chow or high fat chow reveals compromise of blood brain barrier in APOE-ko and in APOE4-ki mice fed hig...
by frankiesfriend
Fri Jan 25, 2019 5:17 am
Forum: The Social Hour
Topic: If you should choose to drink alcohol -- which is best?
Replies: 34
Views: 9844

Re: If you should choose to drink alcohol -- which is best?

I see no reason to ignore research that is more than five years old unless the methodology has improved or new scientific breakthroughs/insights have led to new testing methods or interpretations. Take a look at the recently discussed Bredesen paper citing research published in 1998. But I do take t...
by frankiesfriend
Wed Jan 23, 2019 10:45 am
Forum: Science and Research
Topic: Gut health research
Replies: 10
Views: 3032

Re: Gut health research

Sorry...my new posting appears to have knocked this very important discussion off of the main forum view, so I am posting here to get it back. I am a new member, and I am finding out how the forums work one error at a time. I am very interested in this discussion, in part because I had symptoms that...
by frankiesfriend
Wed Jan 23, 2019 10:39 am
Forum: Science and Research
Topic: Hypothesis that deficiency of Innate Immunity protein causes AD
Replies: 15
Views: 3203

Hypothesis that deficiency of Innate Immunity protein causes AD

“An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer’s disease – a cohort study of 95,442 individuals.” 2018. Alzheimer’s & Dementia. Rasmussen, K., et al. pages 1 – 13. My non-expert analysis of this research article. Complement C3 is a protein that (along with other proteins) ...
by frankiesfriend
Wed Jan 23, 2019 6:31 am
Forum: The Social Hour
Topic: If you should choose to drink alcohol -- which is best?
Replies: 34
Views: 9844

Re: If you should choose to drink alcohol -- which is best?

I could not find the research article I referenced in an earlier post on this thread, but I did a little digging and uncovered the following articles, many of which are reviews of research articles on this topic, and have provided quotes from the articles: H.M. Schipper, “Apolipoprotein E: Implicati...
by frankiesfriend
Mon Jan 21, 2019 2:12 pm
Forum: Announcements and Events
Topic: FDA Draft of AD biomarkers -deadline for comment 2/11/2019
Replies: 0
Views: 798

FDA Draft of AD biomarkers -deadline for comment 2/11/2019

Perhaps this has already been posted? I saw it on the Alzforum website - The development of biomarkers for Alzheimer’s and other neurodegenerative diseases is accelerating rapidly, with blood tests and new fluid and imaging markers on the horizon. However, developers must contend with an uncertain p...

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