“APOE attenuates unresolvable inflammation by complex formation with activated C1q” – Yin, C, et al, Nature Medicine, online 1/28/2019. Study in mice with APOE ko, APOE3 ki and APOE4 ki fed normal chow or high fat chow reveals compromise of blood brain barrier in APOE-ko and in APOE4-ki mice fed hig...

I see no reason to ignore research that is more than five years old unless the methodology has improved or new scientific breakthroughs/insights have led to new testing methods or interpretations. Take a look at the recently discussed Bredesen paper citing research published in 1998. But I do take t...

Sorry...my new posting appears to have knocked this very important discussion off of the main forum view, so I am posting here to get it back. I am a new member, and I am finding out how the forums work one error at a time. I am very interested in this discussion, in part because I had symptoms that...

“An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer’s disease – a cohort study of 95,442 individuals.” 2018. Alzheimer’s & Dementia. Rasmussen, K., et al. pages 1 – 13. My non-expert analysis of this research article. Complement C3 is a protein that (along with other proteins) ...

I could not find the research article I referenced in an earlier post on this thread, but I did a little digging and uncovered the following articles, many of which are reviews of research articles on this topic, and have provided quotes from the articles: H.M. Schipper, “Apolipoprotein E: Implicati...

Perhaps this has already been posted? I saw it on the Alzforum website - The development of biomarkers for Alzheimer’s and other neurodegenerative diseases is accelerating rapidly, with blood tests and new fluid and imaging markers on the horizon. However, developers must contend with an uncertain p...

Your anxiety is understandable, and it is overwhelming to read about the many aspects of lifestyle changes that would favor brain health. You are fortunate, however, to learn your status when you are so young and can evaluate and modify your lifestyle to avoid developing Alzheimer's. It must have be...

A few months ago I read a review article on alcohol risks and Alzheimer's. I was particularly interested in studies that teased out differences, if any, related to genetics. I found it interesting that there were many research articles that indicated no increased risk of AD with light to moderate al...

Thank you everyone for your insight and for sharing your personal experiences. My mother was only five years older than I am right now when she was diagnosed with AD. She probably had mixed dementia and suffered terribly from delusions and emotional turmoil. Watching this was heartrending, and the q...

I am re-reading Bredesen's "The End of Alzheimer's", having noted that he has an updated version. Just last night, I ran across an assertion that very low triglycerides (especially under 50 mg/dl), are observed in patients who have toxicity-related Alzheimer's. I remember when I read this ...