This paper In the Journal of Alzheimer's Disease describes other AD genetic risks that arise from genes that regulate proteins involved in cholesterol metabolism, amyloid processing and clearance, immune response, and nerve cell protective factors: J Alzheimers Dis. 2018;62(2):887-900. A Network of ...

Heart Rate Variability (HRV) is one indicator of both cardiovascular health and general health, a topic covered pretty well in the Wiki. Many of the wearables like Fitbit and the Oura ring track HRV as well as heart rate and other fitness parameters. I have an OUra ring, which tracks HRV only during...

I have been confused on this issue as well. I do want to lower my homocysteine from 9.8, but I have read that choline intake raised insulin resistance (appears to be an inconsistent result according the studies Julie cited), but also I think I have read that choline supplementation may raise cholest...

I bought an Oura ring about a month before the polysomnography (PSG) study I underwent about three months ago. The PSG indicated I had mild sleep apnea during REM sleep, and ZERO deep sleep. My sleep doctor recommended a CPAP but did not seem to care about the deep sleep. When I pressed for more inf...

A new review paper in the Journal of Neurodegenerative Diseases recounts the familiar lifestyle recommendations of healthy diet, lower stress, exercise and sleep for lowering the risk of developing Alzheimer's, as well as treating early symptoms. Additionally, the authors cite lithium deficiency as ...

Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment JAMA Network Open, September 27, 2019 - Koch, Manja, et al. (Article is open to the public, but I could not get a hyperlink to work.) This study extracted data from the Gingko ...

I have been doing 16:8 IF for several years, but I have been thinking for a long time that I should embark on longer fasts, as is recommended by many in this forum who have benefited as well as many in the functional medicine health podcast arena. My overall goal would be as a tune up of general hea...

After spinal fusion surgery on my lower back six years ago, I developed neuropathic symptoms (deep, aching pain and parathesias in my legs and feet), which greatly impacted my stamina and mobility. My neurologist prescribed gabapentin for neuropathy, but offered no other treatment. I sought a second...

This impressive research hints at the mechanisms by which physical activity protects the aging brain. "Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline" Nicole C. Berchtold a,*, G. Aleph Prieto a, Michael Phelan b,...

In a typical polysomnography used to evaluate sleep apnea or other sleep disorders, do they look at spindle coupling and amplitude which is indicated in this paper to correlate to tau and amyloid accumulation? I am interested in obtaining a sleep study due to a recent history (five years) of poor sl...