If you login to 23andme, browse to your raw data and check these two SNPs: rs429358 and rs7412 Then consult this page: https://www.snpedia.com/index.php/APOE ApoE2, ApoE3, and ApoE4 make-up 99% of the apoE genotypes. You have a better chance of winning the lottery than having a genotype other than a...

Thanks Stavia! Very Interesting! When you contact him, can you get a bit more information about what "metabotypes" PLS1, PLS2, and PLS3 actually represent. A description of that seems to be missing from the slides. My basic take home message is that his hypothesis fits with the epidemiolog...

Unfortunately this is an example where something promising in mouse models does not pan out. Today Merck announced they are stopping work on their BACE inhibitor, which is the approach mentioned in the news story above. Here are the details: https://www.alzforum.org/news/research-news/merck-pulls-pl...

It will be important for follow-up research to delve into the particular formula that might have facilitated the 4's ability to steer clear of the plaques. By my counting, about 20% of the E4 carriers in the study were amyloid-free vs. 60% of E4 non-carriers. It would be very interesting to know wh...

High APOE in CSF associated with AD reflects leaky BBB. Low APOE in plasma probably reflects low synthesis by astroctes. Problem with APOE4 is lack function. Therefore if in old age E3 synthesize less will cause less function. In mouse studies APOE null mice same as APOE4 mice. Decrease APO3 in old...

This has been discussed several times before. I think this thread:https://www.apoe4.info/forums/viewtopic ... sen#p29120 is a good summary of the positives and negatives of the study.

Eduardo, I really like your analogies. In thinking about all this, Alzheimer's disease is really about resources more than about the observable pathology. Let's say money (glucose), is slipping away from a neighborhood, and the government (neuroenergetic governance) responds incorrectly. The governm...

I ordered Integrative Therapeutics Theracurmin because it appears to precisely match what was used in the study (each capsule has 90mg of active ingredient). I can't say I notice any difference between the various forms I took in the past (currently taking Longvida), but I will also check back in. O...

Thanks for posting this Julie. I said I doubted we would see this kind of trial, and even though it is a small trial I am happy to be proven wrong. Gary Small is a bit of a controversial figure, as he has received a warning letter from the FDA about his attempts to market the PET scan used in the st...

There are now 3+ threads discussing this, so maybe we can consolidate on one? The Alzheimer's UK numbers are much lower than what is typically reported. Here are some numbers from the Banner Institute, who are running an ApoE4/4 clinical trial (The Generation Study) https://www.ncbi.nlm.nih.gov/pmc/...