Hi Cvd. Always good to watch out for conflicts of interest, but the work on homotaurine has been conducted by several independent groups over the years, and this recent paper by the Czech group is the kind of breakthrough paper that people wouldn't put their names on without being certain the resear...

I tested positive for COVID on Monday, and since APOE-ε4 is associated with greater risk of long COVID, I decided I would up my intake of homotaurine to 450 mg / day.

The nausea is mostly gone. For me, the key seems to be to spread out the doses, and try to take it with food.

Hi Kathleen. I get it here:

https://www.supersmart.com/en/shop/brai ... ement-0661

I'm currently taking 300 mg/day in divided doses.

Brian

If my nausea doesn't go away I'm going to do a bulk order of valiltramiprosate (valylamide prodrug of homotaurine) from a chemical supply house. Actually... no: I can't find a non–prohibitively high price. Since yesterday the nausea is mostly gone, fortunately (and that, despite having COVID and be...

Thanks Tincup. Yes, I saw the older thread. One of the things I cherish about this group are the detailed reports from people about their self-experimentation. I always take those reports into account when making my own health decisions. But I also look closely at published science. My take-away abo...

I just started three days ago. So I'm hoping that the nausea -- experienced by around 20-25% of the people who take homotaurine -- is just me adjusting, or caused by something else. My still somewhat cursory look at the literature (I'll be diving in more deeply soon) made me conclude that the best d...

https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00620-9 This is amazing news. It would explain why trials show an allele-dose effect (homozygote > heterozygote > non-carrier). Although note that an older paper suggests that the molecule being corrected is Aβ42: https...

Hi everyone. Thanks for the great ideas.

Salmon roe looks like a great choice. Be sure to check ingredients. A lot of salmon roe products contain sorbitol (again: this might not be a problem, but many of us may want to avoid sorbitol).

ChicagoGirl, like TeaandGlasses – and I suspect everyone here – I'm grateful for your taking the time to document your experience. Invaluable! And thank you to everyone else who also has made this such a useful and inspiring discussion. I want to note something in the event others try to join this t...

The gene therapy field is exploding with ideas. CRISPR-cas and other gene-editing techniques are under development for a number of neurodegenerative conditions, though I'm more hopeful about the work being done in David Liu's lab, which involves precisely changing one nucleotide ("letter")...