Kudos to Julie to putting together a stellar lineup of fantastic speakers. She also did a spectacular job addressing a packed audience at the Buck, prior to Dr. Bredesen's talk. Also thanks to Julie, not just for the yeoman's work of putting this together, but also for her personal touch that made these connections with these awesome investigators possible. All of these very high-powered researchers were anxious to meet and talk with us, thanks to Julie. Also thanks to Stavia for her personal touch, creating connections on the fly, that will pay many dividends in the future.
- Julie did a wonderful job on her talk and creating a connection for our group.
- Dr. Bredesen's talk was very much like the one previously linked here that he gave to the California State legislature a few weeks ago.
- There is a handout that I'm sure someone will scan and post here on his tweeks to his protocol (we're on holiday for another week).
- Bredesen told me he's working on a book to tell everyone how to do this on their own- how to order tests & get supplements. No mention of when it might be done.
- One of Bredesen's top associates, Rammohan V Rao, gave us a tour of his lab and described his work. His publications are here: http://www.researchgate.net/profile/Rammohan_Rao4/publications
. Turns out he is also published this paper on Ayurvedic herbs for AD: http://alzres.com/content/4/3/22
. He says he's an 3/3, but follows all of the MEND prescriptions, too.
- Dr. Krauss was very interesting but no clear cut guidelines for us. Asked about an appropriate level of LDL-P for us and he said 1,500, 1,200, 1,000 or less might be appropriate, depending on the individual. My opinion is that serial EBT calcium scans https://www.apoe4.info/forums/viewtopic.php?f=5&t=1355&hilit=EBT
are the best way to answer the heart disease question.
- Drs. Mahley & Huang presented their work. In a nutshell, the neuron expresses ApoE for repair, in response to an insult. It can see the differently shaped 4 protein as a problem and attack it (this can also happen to 3, but much less frequently). As a result there are protein fragments that can build up. Quantities of these fragments are correlated with cognitive decline.
- They are working on a fragment assay
- They are working on molecules to "fix" the shape of the ApoE protein so it won't be attacked. This work as been done in mouse models.
- The body can "clean up" fragments if the clean up mechanisms aren't overwhelmed by new fragments.
- They are working with a venture capital investment group to create a startup to take the testing and molecules to the next step. They are very close to launching. The CEO chosen by the venture group to make this happen, Leon Chen, also addressed us. He is a PhD scientist with a B-School degree who has done this numerous times. He is very impressive.
- Mahley discovered the E4 gene. When asked where is the E1, he said, "that was a mistake, we thought there was an E1, but it turned out to be a glucose saturated E2. There is no E1."