Thank you, Xing. We like a little good news once in a while . Previous studies have shown that E4 carriers have some protection against many cancers. My guess is that this may be due to our premature apoptosis secondary to a down-regulation of our mitochondria. It makes sense, that the more advantaged E2s could be at higher risk. My E2 husband has had many skin cancer scares. It’s interesting to view this through the APOE lens.
I had just finished searching APOE4 site and could find ANYTHING specific about APOE4 except for one picture chart that alluded to things of interest but had no citations or clarification.
For some unknown reason it had not occurred to me that APOE 4 was mechanistically different than the others and there might be unique "therapies." Why is this not a topic on the website? I'll be looking for more information.
The site has abundant information on Alzheimer's issues in general. How should I tailor my life specifically knowing that I am APOE4 aside from generalized Alzheimer's prevention, slowing or cure?
cflegal wrote:I had just finished searching APOE4 site and could find ANYTHING specific about APOE4 except for one picture chart that alluded to things of interest but had no citations or clarification.
For some unknown reason it had not occurred to me that APOE 4 was mechanistically different than the others and there might be unique "therapies." Why is this not a topic on the website? I'll be looking for more information.
The site has abundant information on Alzheimer's issues in general. How should I tailor my life specifically knowing that I am APOE4 aside from generalized Alzheimer's prevention, slowing or cure?
Hi cflegal,
It can be confusing to jump into the middle of a lot of forum posts that assume a pretty high level of knowledge about ApoE 4--and I say that as someone who has been reading posts since 2016! Here are some links to the background information that may help:
Not everyone on the site follows the Bredesen Protocol, named after Dr. Dale Bredesen. But many people follow at least some of his ideas. You can see an overview and explanation on our Wiki (like our version of wikipedia) here: The Bredesen Protocol
cflegal wrote:I had just finished searching APOE4 site and could find ANYTHING specific about APOE4 except for one picture chart that alluded to things of interest but had no citations or clarification.
For some unknown reason it had not occurred to me that APOE 4 was mechanistically different than the others and there might be unique "therapies." Why is this not a topic on the website? I'll be looking for more information.
The site has abundant information on Alzheimer's issues in general. How should I tailor my life specifically knowing that I am APOE4 aside from generalized Alzheimer's prevention, slowing or cure?
Hi cflegal,
It can be confusing to jump into the middle of a lot of forum posts that assume a pretty high level of knowledge about ApoE 4--and I say that as someone who has been reading posts since 2016! Here are some links to the background information that may help:
Not everyone on the site follows the Bredesen Protocol, named after Dr. Dale Bredesen. But many people follow at least some of his ideas. You can see an overview and explanation on our Wiki (like our version of wikipedia) here: The Bredesen Protocol
I hope this helps!
Disclaimer: I am one of the co-founders of Dash Genomics.
. Previous studies have shown that E4 carriers have some protection against many cancers. My guess is that this may be due to our premature apoptosis secondary to a down-regulation of our mitochondria. It makes sense, that the more advantaged E2s could be at higher risk. My E2 husband has had many skin cancer scares. It’s interesting to view this through the APOE lens.
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