Beautiful analogy, but it works the other way too. Someone who becomes ill eating leafy greens (aka lectinsSo, when large-scale studies show benefits from an intervention (eg., green leafy vegetables improve well-being in many ways), then the unfavorable N=1 outcomes or adverse effects in an individual (eg., too frequent bowel movements) don't overturn the findings of the large-scale study for others.
) would be ill-advised to rely on large scale scale studies, centered on the promotion of leafy greens, for health advice. As a likely non-E4 carrier, you seem to be missing the point of our project. We encourage folks to share their N=1s. In fact, we speak most authoritatively when doing so. By sharing, we hope that a signal will emerge. The APOE-ε4 gene has been described by multiple researchers as being pro-inflammatory. When many of our members (multiple N=1s) indicate that eating a diet high in lectins causes inflammation, that's something we tend to pay attention to. When Dr. Gundry, who has a large E4 practice, can substantiate those inflammatory symptoms with inflammatory markers (that are highly correlated with mortality) that's of interest to us. That said, we must look at this E4 specific micro-evidence within a macro context. In no way are we dismissing the broader work that you prefer to focus upon. Instead, we spend much of the time delving into the paradoxes that result between the two.
