Female Chromosomes Offer Resilience to Alzheimer’s

[circular]

Some good -- and interesting -- news for women and potential therapeutics:

Female Chromosomes Offer Resilience to Alzheimer’s

[Rosemary]

Hi Circular,
Thanks for forwarding what looks like good news for women and men associated with the X chromosome. I did a quick google search looking for protective variants and associated SNPs. Here's what I found:
https://www.alzforum.org/news/research- ... alzheimers

Here's what they say:
"They searched for variants associated with elevated KDM6A expression in the brain, and, sure enough, identified a common variant, rs12845057, whose minor allele, an adenosine, is carried by roughly 14 percent of the global population and associates with more KDM6A expression in the brain. To see if this variant associated with cognitive resilience, the researchers looked for it among 778 volunteers in the Alzheimer’s Disease. " See the graph for more details.

I logged into 23andme, and unfortunately no results for me. If anyone tries this, and they succeed, please let me know what platform they are using.

[circular]

Hi Circular,
Thanks for forwarding what looks like good news for women and men associated with the X chromosome. I did a quick google search looking for protective variants and associated SNPs. Here's what I found:
https://www.alzforum.org/news/research- ... alzheimers

Here's what they say:
"They searched for variants associated with elevated KDM6A expression in the brain, and, sure enough, identified a common variant, rs12845057, whose minor allele, an adenosine, is carried by roughly 14 percent of the global population and associates with more KDM6A expression in the brain. To see if this variant associated with cognitive resilience, the researchers looked for it among 778 volunteers in the Alzheimer’s Disease. " See the graph for more details.

I logged into 23andme, and unfortunately no results for me. If anyone tries this, and they succeed, please let me know what platform they are using.

Thanks. I'm on 23andMe version 3 ... no dice. I have the kit to upgrade but haven't gotten around to it. What version of 23ande do you have?

[Rosemary]

I also have version 3 of 23andMe. Like you, I'm thinking of upgrading to version 5, but there's no telling if the common variant rs12845057 will be covered. If someone on this forum has version 5, please consider checking for rs12845057, Thanks.

[anotherdreamer]

I also have version 3 of 23andMe. Like you, I'm thinking of upgrading to version 5, but there's no telling if the common variant rs12845057 will be covered. If someone on this forum has version 5, please consider checking for rs12845057, Thanks.

I’ve got version five and it’s not showing on mine either. It might not be checked.

[Rosemary]

Hi anotherdreamer,
Thank you kindly for checking this out!! I guess, for now, I'll wait to update to version 5.
Donna

[anotherdreamer]

Hi anotherdreamer,
Thank you kindly for checking this out!! I guess, for now, I'll wait to update to version 5.
Donna

Maybe we’ll luck out with the next version : )