Dr Mercola interviews Dr. Perlmutter

[bucci_angel]

Angela, if you search on this site you can see/hear more recent interviews. [emoji177]


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Hello it is me again Angela.....was not able to open link to see video but found another video on YouTube. I was wondering if I should get my mom tested genetically for APOE....we do not have AD in the family but not sure if she is type 3....She is trying to quit smoking on her own which she has decreased to almost 1 or2 but not a full cigarette. She is on a number of supplements suggested by Dr.Bredessen....but there are some supplementsshe can't take because of the thyroid med the synthroid.....she is on aircept and I read that there maybe an interaction with bacopa monnieri....could the aircept be making her worse.....or the combination with supplements....It seems that she is getting worse...could it be the diminished almost to no smoking be causing some of the getting worse with the word finding mixing up pronouns or time instead of saying 7 pm she will say 9 pm but she meant 7pm things like this
I feel like the examples of cases are persons who are not on aircept and seems different when it comes to symptoms.....maybe she is not mild to moderate.....She is a bilingual Italian English speaking and speaks two Italian dialects and sometimes it feels like she has difficulty pronouncing words
I know Dr Bredessen is a busy individual would it be possible for me to e-mail him.
Slowing it's progression would be great reversing some of the symptoms would be amazing
She is seeing her geriatrician at end of May and he will probably increase the meds to full dosage 5mg of aircept and was talking about combining get it with another drug I think he said something like exelon......my mother things she needs more aircept.
I feel frustrated because I feel I am not well informed when I go to see doctors whether the geriatrician or functional doctor....


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[GOLDTHREAD]

Angela!

You're doing wonderfully. I identify with your frustration. You will learn. I was interested in the brain and neouroplasticity and how talent is acquired when my friend began experiencing memory difficulty. And am now still just piecing a lot of this together...

But I'm finding my knowledge is building.

First I'd dive in with Stavia's primer.

Then maybe...
Avoid simple carbs.
Embrace healthy fats-
organic raw high polyphenol olive oil.
MCT Oil - caprylic acid

Eat nine cups of vegetables a day.
Green leafy
Colorful
Cruciferus, sulphur vegetables

Grass fed pasture raised organic if you eat animal products

Embrace dental hygiene flossing brushing

Intermittent fasting - 3 hrs before sleep

If you can get your mom to walk and exercise, exercise, exercise

How wonderful she's cutting out smoking

Your mom might want to do 23&me and learn her apoe4 status as well as many other key markers

I'm on my way out the door but am happy to stay in touch

My belief is if the person experiencing memory loss can be supported to make lifestyle changes
Causes of memory loss can be determined
And those treated
Things will reverse

Kathleen started by checking her homocysteine, vitamin d, zinc, pregnenolone, A1C...

More soon.

There is such rich info here and support and experience.

Much love to you ms. Bucci! One of our best friends here shares your last name[emoji813]️[emoji813]️[emoji813]️
Kimberly



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[bucci_angel]

Angela!

You're doing wonderfully. I identify with your frustration. You will learn. I was interested in the brain and neouroplasticity and how talent is acquired when my friend began experiencing memory difficulty. And am now still just piecing a lot of this together...

But I'm finding my knowledge is building.

First I'd dive in with Stavia's primer.

Then maybe...
Avoid simple carbs.
Embrace healthy fats-
organic raw high polyphenol olive oil.
MCT Oil - caprylic acid

Eat nine cups of vegetables a day.
Green leafy
Colorful
Cruciferus, sulphur vegetables

Grass fed pasture raised organic if you eat animal products

Embrace dental hygiene flossing brushing

Intermittent fasting - 3 hrs before sleep

If you can get your mom to walk and exercise, exercise, exercise

How wonderful she's cutting out smoking

Your mom might want to do 23&me and learn her apoe4 status as well as many other key markers

I'm on my way out the door but am happy to stay in touch

My belief is if the person experiencing memory loss can be supported to make lifestyle changes
Causes of memory loss can be determined
And those treated
Things will reverse

Kathleen started by checking her homocysteine, vitamin d, zinc, pregnenolone, A1C...

More soon.

There is such rich info here and support and experience.

Much love to you ms. Bucci! One of our best friends here shares your last name[emoji813]️[emoji813]️[emoji813]️
Kimberly



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Hi Kimberley
Just was wondering if you or others could help me understand some of the numbers from blood work done on my my mother by a functional doctor outside the Toronto area who is not fa.iliar with Dr. BRDESEN's work but will be as attends conference in June....she is very familiar with Dr. Premultter's work

What is very concerning to me was her Thyroid Peroxidase antibodies which was tested for the first time.....it was at 815 KIU/L
My mom was diagnosed with hypothyroidism in 2011 and was is on synthroid 112mg already
A high TPO is an indication of Hashimotos thyroditis...or autoimmune disease
Now I ha e been researching Hashimotos thyroditis and found out that there is a specific type of Hashimotos called Hashimotos Encephalopathy(HE)which is an autoimmune chronic lymphocytic type of thyroditis which is underdiagnosed which affects the neurological system....and the symptoms are like a progressive dementia....many of the symptoms my mom has are like those described for HE. Many persons are misdiagnosed with other diseases like dementia-AD . There a number of cases in the US and in Europe....it it treated with steroids medrol a type of prednisone 4-6mg.....The problem is when I mentioned it to the fu criminal doctor right away she said no steroids have bad consequences......but what if she has this......how can I rule it out and make sure
I thought that the fun tional doctor would of said to see a specialist an endocrinologist but no she wants to put her on synthroid 50 mg and T3 cytomel 5mg twice a day....not sure if this is will helo

Her T4 22pmol/L and her Free T3 is 3.7pmol/L her reverseT3 is 22.0 ng/dl
Her CRP sensitivity is 4.6mg/L
Vitamin D 127 nmol/L
A1C 5.1%
DHEA 2.6umol/L
Zinc is 15.4umol/L which is considered high out of range
Her insulin baseline was low at 29pmol/L which doctor could not understand why
Her albumin was 43 g/L
B-12 1475 miu/L
She will be checking for food intolerance as well as celiac disease is this necessary
I AM UNSURE what to do next feel overwhelmed....Not sure who to trust
It seems that Her difficulty finding words has I creased and her ability to not express herself easily frustrates her....she goes in between languages Italian and English which used to be so easy for her and now finds it difficult with remembering recipes how to cook certain things..... CAN anyone help....

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[Julie G]

Angela, great detective work! Given your mom's extraordinarily high levels of thyroid peroxidase antibodies, Hashimoto's Encephalitis is a definite possibility. I'm sure you've read this 2014 paper, Hashimoto's Encephalitis: Unusual Cause of Reversible Dementia. I found one that is more recent and also delves into treatment:

Given that EAAT is considered an inflammatory condition, the current treatment is based on immunotherapy. The most commonly used treatment is intravenous methylprednisolone (500–1000 g/day, for 3 to 5 days) followed by oral prednisone (1-2 mg/kg/day), which is gradually tapered with clinical improvement. Immunosuppressants, more commonly azathioprine, may be used as steroid sparing agents [3].
A prompt response to steroids occurs in most patients, usually with a favourable prognosis [3]. However, there is only partial benefit in some patients, no response to steroids is seen in a few cases, and, even after successful treatment, some patients may have relapses, usually during treatment withdrawal [3, 13, 25, 37–40]. However, the absence of response to steroids should not be regarded as a factor against this diagnosis, and other immunotherapies must be tried in cases of strong clinical suspicion. In cases of suboptimal or absent response to first-line treatment with steroids, good results have been reported with immunosuppressants (methotrexate, azathioprine, and cyclophosphamide), periodic intravenous immunoglobulin [41, 42], and plasma exchange [25]. More recently [43] a role for levetiracetam in patients ineligible to steroid treatment has been suggested, as having, in addition to its antiepileptic effects, a possible anti-inflammatory effect mediated through interleukin-1 beta and transforming growth factor beta 1.

Given that your mom's symptoms are worsening on her current treatment, I think it's important that you find a practitioner who's willing to aggressively and appropriately treat this rare condition.

Her insulin isn't low at 4.17 mIU/L. That's perfectly within Dr. Bredesen's recommended level of <4.5. Her CRP is elevated and in line with the suspected encephalitis. I'm so proud of you for finding this potentially treatable condition. You're an amazing daughter. Keep advocating for her, my friend. -XO