aphorist wrote:Aren't you concerned about a B12 level so high?
As a former vegan, with two half MTHFR mutations, not to mention my 4/4 status I’m ecstatic about having gotten my B-12 levels up.
When googling B-12, all the talk seems to be about deficiency which can lead to damage especially in the brain and nervous system.
According to Wikipedia (accessed 26 Feb 2018) – “Elevated levels of serum B12 (cobalamin above about 600 pmol/L) in the absence of dietary supplementation or injections may be a diagnostic sign of serious disease. In such cases B12 is thought to be a marker for disease, not the causal agent.” But I’m supplementing and have no other indications of disease.
So your comment
aphorist wrote:Show that lab value to an oncologist and ask him what he thinks about the long-term cancer risk of being in the top 1%ile of B12 serum levels and he'll probably not have the same viewpoint.
led me to refer to the book The Metabolic Approach to Cancer,
co-written by Dr Nasha Winters, who is an integrative oncologist.
She speaks about the importance of B12 repeatedly
in her book saying “this vitamin plays a starring role in maintaining genetic health.”
Also from the book:
Practicing a ketogenic diet, fasting, balancing amino acids, increasing methyl-donor and folate-rich foods, optimizing B12 levels, and consuming specific plant derived phytonutrients are the cornerstones of our genetic enhancement strategy.
And there is a growing body of evidence that certain dietary compounds - including folate, Vitamin B-12, tea polyphenols, cruciferous vegetables, and more have anticarcinogenic properties because of their relationship to DNA.” (footnote: Gordana Supic, Maja Jagodic, and Zvonko Magic, “Epigenetics: A New Link between Nutrition and Cancer,” Nutrition and Cancer 65, no. 6 (August 2, 2013): 781– 92, doi: 10.1080/ 01635581.2013.805794.)
Now she does caution about fortified forms of B12 being toxic. The book also says,
However, the form of B12 used in fortified cereals, bread products, milk, brewer’s yeast, supplements, and other foods is cyanocobalimin, produced using the chemical form of cyanide (potassium cyanide). Cynocobalimin is not a naturally occurring B12 despite its ability to raise B12 deficiency clinically. This artificial form of Vitamin B12 is mitochondrial poison!