Bredesen Protocol

Dr. Dale Bredesen, of the Buck Institute for Research on Aging and UCLA's Mary S. Easton Center for Alzheimer's Disease Research, is a scientist who has been studying Alzheimer's disease for 30 years and has come up with a way to reverse it in its early stages. His initial protocol involved 25 different interventions which individually don't make a big difference, but together can provide powerful synergistic benefits.

Each intervention is tweaked over time by using blood tests, body measurements, imaging and similar guides to measure its effect. In his initial paper, nine out of ten patients reversed their memory problems and returned to their former healthy level of functioning. The one who didn't show improvement was past the early stages of Alzheimer's.

Dr. Bredesen has since expanded the protocol and number of patients seen. He is in the process of making it available to the wider public with the help of doctors certified in the protocol through MPI Cognition.

Dr. Bredesen was previously affiliated with Muses Labs.

This page sets out to explain the 25 treatments in simple enough language that untrained people suffering from Alzheimer's (or their caregivers) can begin to implement the easier ones while working with their doctors or other labs to begin the others.

Here are the interventions used in The Bredesen Protocol™ to reverse mild Alzheimer's:

1. Optimize diet

2. Enhance autophagy, ketogenesis

3. Reduce stress

4. Optimize sleep

5. Exercise

6. Brain stimulation

7. Homocysteine less than 6 (earlier version of the protocol was < 7)

8. Serum B12 greater than 500

9. CRP less than 1.0; A/G greater than 1.8 (earlier version of the protocol was > 1.5)

10. Fasting insulin less than 5; HgbA1c less than 5.6 (earlier version of the protocol was Fasting insulin <7; HgbA1c <5.5)

11. Hormone balance

12. GI health

13. Reduction of Aß

14. Cognitive enhancement

15. 25OH-D3 = 50-80ng/ml (earlier version of the protocol was 50-100)

16. Increase NGF

17. Provide synaptic structural components

18. Optimize antioxidants

19. Optimize Zn:fCu ratio

20. Ensure nocturnal oxygenation

21. Optimize mitochondrial function

22. Increase focus

23. Increase SirT1 function

24. Exclude heavy metal toxicity

25. MCT effects

26. Inhalational Alzheimer's

Lab testing information

Supplement ordering

For further reading and information on Dr Bredesen's reseach

Dr Bredesen has a book, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline, published August 22, 2017. Amazon link to Dr Bredesen's book

In addition to videos available on the MPI Cognition website www.mpicognition.com, there is also a long, and very good STEM Talk interview with Dr Bredesen available on YouTube Episode 12 Dale Bredesen discusses the metabolic factors underlying Alzheimer’s Disease

The first version of Dr Bredesen’s protocol (which is similar to the above) can be found in his paper: Reversal of cognitive decline: A novel therapeutic program, published September 2014, https://www.ncbi.nlm.nih.gov/pubmed/25324467

Subsequent papers of Dr Bredesen do not address his protocol, but further examine his findings, they are:

Metabolic profiling distinguishes three subtypes of Alzheimer's disease, published in August 2015, https://www.ncbi.nlm.nih.gov/pubmed/26343025

Direct Transcriptional Effects of Apolipoprotein E published January 2016, Dr Bredesen is co-author. https://www.ncbi.nlm.nih.gov/pubmed/26791201

Inhalational Alzheimer’s Disease: An unrecognized – and treatable epidemic, published February 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789584/